A Mathematical Model of Thyroid Disease Response to Radiotherapy

We present a mechanistic biomathematical model of molecular radiotherapy thyroid disease. The general consists set differential equations describing the dynamics different populations cells with varying degrees damage caused by (undamaged cells, sub-lethally damaged doomed and dead cells), as well thyroglobulin antithyroglobulin autoantibodies, which are important surrogates treatment response. is presented in two flavours: on one hand, deterministic continuous model, useful to fit populational data, other stochastic Markov particularly investigate tumor control probabilities individualization. was used response (tumor/thyroid volumes, autoantibodies) observed experimental studies cancer Graves' disease treated I-131-radiotherapy. A qualitative adequate fitting data achieved. also individualization strategies for differentiated cancer, aiming improve probability. found that simple based absorbed dose radiosensitivity (which both magnitudes can potentially be individually determined every patient) lead an raise probabilities.